Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection
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چکیده
منابع مشابه
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours – A prognostic test after surgical resection
No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis typ...
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Malignant peripheral nerve sheath tumours (MPNST) are aggressive sarcomas that develop in about 10% of patients with the genetic disease neurofibromatosis type 1 (NF1). Molecular alterations contributing to MPNST formation have only partially been resolved. Here we examined the role of Pten, a key regulator of the Pi3k/Akt/mTOR pathway, in human MPNST and benign neurofibromas. Immunohistochemis...
متن کاملExpression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNST) are rare, highly aggressive sarcomas that can occur spontaneously or from pre-existing plexiform neurofibromas in neurofibromatosis type1 (NF1) patients. MPNSTs have high local recurrence rates, metastasize easily, are generally resistant to therapeutic intervention and frequently fatal for the patient. Novel targeted therapeutic strategies are u...
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Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessne...
متن کاملAdjuvant Treatment For Patients With Malignant Peripheral Nerve Sheath Tumours
Matthias Kolberg1,2,3 Sigbjørn Smeland2,4 and Ragnhild A Lothe1,2,3,4* 1Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo Norway 2Clinic for Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway 3Center of Cancer Biomedicine, University of Oslo, Oslo Norway 4Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2015
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2015.02.005